EDUCATION

Undergraduate, 2001/3~2005/2, Biological Sciences, Korea University

Graduate, 2005/8~2015/8, Interdisciplinary Program in Neuroscience, Seoul National University

RESEARCH EXPERIENCES

2010/7~2014/06, Researcher, KIST

2014/07~2015/6, Visiting Graduate student, KIST

2016/7-present, Post doctoral fellow, KIST

EXPERICENED RESEARCH SKILLS

Slice Patch (Neuron and Astrocyte), Immunohistochemistry, Confocal imaging, Behavioral Test (passive avoidance test, open field test, fear conditioning, elevated plus maze), Molecular Biological Techniques (Cloning, Subcloning and RT-PCR), Stereotaxic Surgery, Cell Culture (Primary astrocyte, Primary neuron, and Cell line)

PUBLICATIONS

1. Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors. Park H, Han KS, Seo J, Lee J, Dravid SM, Woo J, Chun H, Cho S, Bae J, An H, Koh W, Yoon BE, Berlinguer-Palmini R, Mannaioni G, Traynelis SF, Bae Y, Choi SY, Lee C. Mol Brain. 2015 Feb 3;8(1):7 2. Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition Bo-Eun Yoon, JunsungWoo, Ye-Eun Chun, Heejung Chun, Seonmi Jo, Jin Young Bae, Heeyoung An, JooOkMin, Soo-Jin Oh, Kyung-Seok Han, Hye Yun Kim, Taekeun Kim, Young Soo Kim, Yong Chul Bae and C. Justin Lee. J Physiol. 2014 Sep 19. 3. GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease, Seonmi Jo, Oleg Yarishkin, Yu Jin Hwang, Ye Eun Chun, Mijeong Park, Dong Ho Woo, Jin Young Bae, Taekeun Kim, Jaekwang Lee, Heejung Chun, Hyun Jung Park, Da Yong Lee, Jinpyo Hong, Hye Yun Kim, Soo-Jin Oh, Seung Ju Park, Hyo Lee, Bo-Eun Yoon, YoungSoo Kim, Yong Jeong, Insop Shim, Yong Chul Bae, Jeiwon Cho, Neil W Kowall, Hoon Ryu, Eunmi Hwang, Daesoo Kim & C Justin Lee Nat Med. 2014 Jun 29. 4. AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic plasticity in Aplysia. Lee YS, Choi SL, Jun H, Yim SJ, Lee JA, Kim HF, Lee SH, Shim J, Lee K, Jang DJ, Kaang BK. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15520-5. Epub 2012 Sep 4. 5. PKA-activated ApAF-ApC/EBP heterodimer is a key downstream effector of ApCREB and is necessary and sufficient for the consolidation of long-term facilitation. Lee JA, Lee SH, Lee C, Chang DJ, Lee Y, Kim H, Cheang YH, Ko HG, Lee YS, Jun H, Bartsch D, Kandel ER, Kaang BK. J Cell Biol. 2006 Sep 11;174(6):827-38. 6. Regulation of ApC/EBP mRNA by the Aplysia AU-rich element-binding protein, ApELAV, and its effects on 5-hydroxytryptamine-induced long-term facilitation. Yim SJ, Lee YS, Lee JA, Chang DJ, Han JH, Kim H, Park H, Jun H, Kim VN, Kaang BK. J Neurochem. 2006 Jul;98(2):420-9. 7. SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses.Ko J, Kim S, Chung HS, Kim K, Han K, Kim H, Jun H, Kaang BK, Kim E. Neuron. 2006 Apr 20;50(2):233-45.

Education

2013.03 – 2017. 02 Ph.D. from College of Korean Medicine, Kyung Hee University 
Advisor: Kwang Seok Ahn, Bum Sang Shim 
Mentor: Justin C. Lee (Korea Institute of Science and Technology) 
Honors: 1st prize of oral presentation at annual workshop of Brain Science Institute, KIST (2014), Poster award at 2015 Glia Meeting Korea (2015), Poster award at Brain conference 2015 (2015), 2nd prize of oral presentation at KIST Junior R&D Expo (2016), Poster award at 2017 Glia Meeting Korea (2017)

2011.03 – 2013.02 M.S. from College of Korean Medicine, Kyung Hee University 
Advisors: Kwang Seok Ahn, Seung-Hoon Choi 
Mentor: Kwang-Sup Soh (Seoul National University) 
Thesis: Investigation of the primo vascular system underneath the superior sagittal sinus in the brain 
Honors: Korea Junior Research Fellowship (2012~2015)

2004.03 - 2011.02 MD (Korean Medicine) and B.S. from College of Korean Medicine, Kyung Hee University 
Honors: Youth Heojun Award (2010), Korea Presidential Youth Talent Award (2010), Dean's honored graduate (2011)

2001.03 - 2004.02 Korean Minjok Leadership Academy (민족사관고등학교)

Experience 
Center for glia-neuron interaction, Brain Science Institute, Korea Institute of Science and Technology 
Post-doc, 2017.03 – present

Lab for glia-neuron interaction, Center for Neural Science and Center for Functional Connectomics Center, Korea Institute of Science and Technology 
Visiting graduate student, 2013.03 – 2017.02

Nano Primo Research Center, Advanced Institute of Convergence Technology, Seoul National University 
Visiting graduate student, 2011.03 – 2013.02

Department of Pathology, College of Korean Medicine, Kyung Hee University 
Research assistant, 2011.03 - 2012.03

Biomedical Physics Laboratory, College of Physics & Astronomy, Seoul National University 
Researcher, 2011.01 - 2011.02

Publications – papers

Lee SW*, Nam MH*, Lee BC, Herbal Acupuncture for Type 2 Diabetes: A Systematic Review, Experimental and Therapeutic Mededicine, 2017, accepted

Nam MH, Jung SJ, Lim J, Seo E, Lim J, Lee SJ, Yoon SZ, Soh KS, A novel fibrous duct structure in the brain meninges discovered using polarized light microscopy, Journal of Korean Physical Studies, 2016;68(10):1246-53.

Nam MH*, Lee SW*, Na HY, Yoo JH, Paik SH, Ahn KS, Ahn YM, Ahn SY, Choi SH, Lee BC, Herbal Acupuncture for the Treatment of Obesity, Journal of Acupuncture & Meridian Studies, 2016, 9(2):49-57.

Kim J, Stefanov M, Nam MH, Kim S, Tracing Mercox Injected at Acupuncture Points under the Protocol of Partial Body Macerations in Mice, Journal of Acupuncture & Meridian Studies, 2015;8(6):314-20.

Nam MH, Ahn KS, Choi SH. Acupuncture: A potent tool for inducing adult neurogenesis, Neural Regeneration Research, 2015;10(1):33-35.

Nam MH*, Baek M*, Lim J, Lee S, Yoon J, Kim J, Lee MS, Soh KS. Discovery of a novel fibrous tissue in the spinal pia mater by polarized light microscopy, Connective Tissue Research, 2014;55(2):147–155.

M. Stefanov, M. Potroz, J. Kim, J Lim, Richard Cha, MH Nam. The Primo Vascular System as a New Anatomical System, Journal of Acupuncture & Meridian Studies, 2013;6(6):331-338.

SJ Jung, KH Bae, MH Nam, HM Kwon, YK Song, KS Soh, Primo Vascular System Floating in Lymph Ducts of Rats, Journal of Acupuncture & Meridian Studies, 2013;6(6):306-318. (Featured article)

Nam MH, Ahn KS, Choi SH. Acupuncture stimulation induces neurogenesis in adult brain, International Review of Neurobiology, 2013;111:67-90.

Lee SH, Bae KH, Kim GO, Nam MH, Choi YB, Kwon HM, Ryu Y, Soh KS. Primo vascular system in the lymph vessel from the inguinal to the axillary nodes, Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 472704, 6 pages, 2013. doi:10.1155/2013/472704.

Bae KH, Park SH, Lee BC, Nam MH, Yoon JW, Kwon HM, Yoon SZ. Novel threadlike structures may be present on the large animal organ surface: evidence in swine model, Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 758763, 5 pages, 2013. doi:10.1155/2013/758763.

Stefanov M, Kim JD, Nam MH, Soh KS. New approach of corrosion casting using direct injection of mercox into the parenchyma of different organs, The Anatomical Record, 2013;296:724–725.

Nam MH, Lim J, Choi SH, Kim SC, Soh KS. A primo vascular system underneath the superior sagittal sinus in the brain of a rabbit, Journal of Acupuncture & Meridian Studies, 2012;5(5):210-217.

Nam MH, Choi SH, Soh KS. Light and primo vascular system in the brain, Journal of the Korean Physical Society, 2012;60(6):903-906.

Nam MH, Yin CS, Choi SH, Soh KS. Adult neurogenesis and acupuncture stimulation at ST36, Journal of Acupuncture & Meridian Studies, 2011;4(3):153-158.

Nam MH, Kim Y, Kim H, Park J, Yeh HY, Lee YS, Lee S, Jung WM, Hong YK, Lee H, Park HJ, Chae Y, A Comparison Study of Factors of Willingness to Use Traditional Medicine between Korean, Chinese and Taiwanese, J Korean Oriental Med 2011;32(1):36-55.

Kim SY, Kim H, Nam MH, Li Y, Chung HC, Park HJ, Lee H, Chae Y, Evaluation of a Traditional Korean Medicine Content Factor and Satisfaction with the Drama ‘Daejanggeum’, The Journal of Korean Acupuncture & Moxibustion Society, 2010;27(1):11-20.

Wuhyun Koh

Birth Date : November 12, 1989

Citizenship : Republic of Korea

Tel : +82-10-6361-2748

Email : whvankoh@gmail.com (general) or whvankoh@ibs.re.kr (institute)

Current Title : Ph. D. course

EDUCATION

2008.03 ~ 2012.08

B.A. in Korea University, Republic of Korea

2013.08 ~ 2018.11

Researcher, Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), Republic of Korea

2013.08 ~ present

Integrated Ph.D. course, in University of Science and Technology (UST), Republic of Korea

2018.02 ~ present

Technical Research Personnel (Mandatory military service in Republic of Korea)

2018.12 ~ present

Researcher, Center for Cognition and Sociality, Institute for Basic Science (IBS), Republic of Korea

RESEARCH INTERESTS

Astrocyte-Neuron Interaction, Reversal Learning

PUBLICATIONS

S.-J. Oh, J. Lee, H.-B. Kim, J. Lee, S. Han, J. Bae, G.-S. Hong, W. Koh, J. Kwon, E.-S. Hwang, D. Woo, I. Youn, I.-J. Cho, Y. Bae, S. Lee, J. Shim, J.-H. Park, J. C. Lee, Ultrasonic Neuromodulation via Astrocytic TRPA1. Current Biology 29, 3386-797583616 (2019)10.1016/j.cub.2019.08.021).

M.-H. Nam, K.-S. Han, J. Lee, W. Won, W. Koh, J. Bae, J. Woo, J. Kim, E. Kwong, T.-Y. Choi, H. Chun, S. Lee, S.-B. Kim, K. Park, S.-Y. Choi, Y. Bae, J. C. Lee, Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference. Cell Reports 28, 1154-116600000 (2019)10.1016/j.celrep.2019.06.071).

J. Woo, Y.-E. Han, W. Koh, J. Won, M. Park, H. An, J. C. Lee, Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient. Experimental Neurobiology 28, 30-42 (2019)10.5607/en.2019.28.1.30).

W. Koh, Y. Park, S. Lee, J. C. Lee, AAV-Mediated Astrocyte-Specific Gene Expression under Human ALDH1L1 Promoter in Mouse Thalamus. Experimental Neurobiology 26, 350-361 (2017)10.5607/en.2017.26.6.350).

H. Park, K.-S. Han, J. Seo, J. Lee, S. M. Dravid, J. Woo, H. Chun, S. Cho, J. Bae, H. An, W. Koh, B.-E. Yoon, R. Berlinguer-Palmini, G. Mannaioni, S. F. Traynelis, Y. Bae, S.-Y. Choi, J. C. Lee, Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors. Molecular Brain 8, 1-16 (2015)10.1186/s13041-015-0097-y).

EXPERIENCES

2009. 06 ~ 2009. 08 48th National Undergraduate Symposium on Biology (NUSB),
Topic : Mitochondia

2010. 06 ~ 2010. 08 49th National Undergraduate Symposium on Biology (NUSB),
Topic : Epigenetics

2010. 06 ~ 2011. 03 Undergraduate Internship Program in Lab of Neuroscience (Dr. Bongjune Yoon), Korea University, Republic of Korea

2011. 06 SURF (Summer Undergraduate Research Fellowship) program in Molecular Neuroscience Lab (Dr. JungHoon Kim), POSTECH, Republic of Korea

2011. 02 ~ 2011. 08 50th National Undergraduate Symposium on Biology (NUSB) Staff,
Topic : Neuroscience

2012. 06 ~ 2012. 08 51st National Undergraduate Symposium on Biology (NUSB),
Topic : Bioinformatics

2013. 04 ~ 2013. 08 Undergraduate Internship Program in Glia-Neuron Interaction Lab
(Dr. C. Justin Lee), KIST, Republic of Korea

AWARDS

1st prize for “Best oral presentation” at the 2018 Brain Science Institute (BSI) annual meeting held in

Pyeongchang, Republic of Korea

Personal Record

Name                                       : Joungha Won

Country of Citizenship            : Republic of Korea

Current Status                     : Post-Doctoral fellow, Center for Cognition and Sociality, Institute for Basic Science (IBS)

E-mail                                      : jwon@ibs.re.kr

Education

2007. 03 ~ 2013. 02               BS, Department of Biology, Kyung Hee University

2013. 03 ~ 2021. 02               Integrated MS/Ph.D, program, Department of Biological Science, KAIST

Academic Appointments

2013. 02 ~                                Ph.D. Candidate, Bio-Imaging and Optogenetics Laboratory, KAIST 
                 (Professor Won Do Heo’s Lab)

2015. 03 ~ 2018. 10                Student Researcher, Center for Neuroscience,

Center for Glia-Neuron interaction, KIST (C. Justin Lee’s Lab)

2018.11 ~                                Student Researcher, Center for Cognition and Sociality,

                                                Cognitive Glioscience Group, IBS (C. Justin Lee’s lab)

Thesis title

Development of optogenetic molecular probe for inhibition of synaptic transmission, and detection protocol for the COVID-19

Research Interests

Activity-dependent astrocytic proBDNF release in Learning and Memory

Activity-dependent and environment-dependent BDNF expression in astrocyte.

Development an optogenetic trap for reversible inhibition of vesicular release, synaptic transmission and behavior

Investigate calcium activity and its functions in astrocyte.

The function of astrocytic molecule in pathophysiological status, especially in stroke and Parkinson's disease.

Diagnostic tool development.

Experimental Techniques

Imaging experiment: Confocal imaging, Live-cell imaging, Intrinsic optical signaling imaging, Super-resolution imaging, Calcium imaging, Total internal reflection fluorescence imaging, multi-photon image, etc.

Electrophysiology: whole-cell patch clamp in acute brain tissue and cultured cell, and field recording

Molecular biology: SNP analysis, cloning, qRT-PCR, diagnosis tool development, etc.

Next-Generation Sequencing (NGS)

Primary culture: primary cortical, hippocampal and spinal cord astrocyte cell culture, cortical neuron culture

Animal behavior experiment: Fear conditioning, Open field test, Novel object/place recognition test, Passive avoidance test, etc.

Histology: Immunohistochemistry, Immunocytochemistry

Optogenetics experiment: Imaging, molecular biology, and behavior experiment with optogenetic tools.

Awards

Best presentation Award, The Korean Society for Brain and Neural Sciences, 2020

Best article award of The Korean Society for Brain and Neural Sciences, The Korean Society for Brain and Neural Sciences, 2021

Best presentation Award, The Korean Society for Brain and Neural Sciences, 2021

Publications

Published

1. Joungha Won, Lee S, Park M, Kim TY, Park GM, Choi BY, Kim D, H Chnag, Heo WD, Kim V. N and Lee CJ., Development of a Laboratory-safe and Low-cost Detection Protocol for SARS-CoV-2 of the Coronavirus Disease 2019 (COVID-19)., Experimental Neurobiology Exp Neurobiol. 2020 Apr;29(2), 11 March (2020)

2. Joungha Won, Hasan Hüseyin Kazan, Jea Kwon, Myungsun Park, Mehmet Ali Ergun, Sureyya Ozcan, Byung Yoon Choi, Won Do Heo^* and C. Justin Lee^*, Ultimate COVID-19 Detection Protocol Based on Saliva Sampling and qRT-PCR with Risk Probability Assessment, Experimental Neurobiology Exp Neurobiol. 2021 Feb 28; 30(1): 13–31.

3. Chang KY, Woo D, Jung H, Lee S, Kim S, Won Joungha, Kyung T, Park H, Kim N, Yang HW, Park JY, Hwang EM, Kim D, Heo WD., Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling., Nature Communications. 2014 Jun 4;5:4057. doi: 10.1038/ncomms5057.

4. Kwon J, An H, Sa M, Joungha Won, Shin JI, Lee CJ., Orai1 and Orai3 in Combination with Stim1 Mediate the Majority of Store-operated Calcium Entry in Astrocyte., Exp Neurobiol 2017 Feb;26(1):42-54. (2017)

5. Woo DH, Bae JY, Nam MH, An H, Ju YH, Joungha Won, Choi JH, Hwang EM, Han KS, Bae YC, Lee CJ, Activation of Astrocytic μ-opioid Receptor Elicits Fast Glutamate Release Through TREK-1-Containing K2P Channel in Hippocampal Astrocytes., Front Cell Neurosci. 2018 Sep 27;12:319. (2018)

6. Woo J, Han YE, Koh W, Joungha Won, Park MG, An H, Lee CJ., Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient., Exp Neurobiol. 2019 Feb;28(1):30-42 (2019)

7. Han YE, Kwon J, Joungha Won, An H, Jang MW, Woo J, Lee JS, Park MG, Yoon BE, Lee SE, Hwang EM, Jung JY, Park H, Oh SJ, Lee CJ., Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRACswell) in the Brain., Exp Neurobiol. 2019 Apr;28(2):183-215 (2019)

8. Park M, Joungha Won, Chio BY, Lee CJ., Optimization of primer sets and detection protocols for SARS-CoV-2 of coronavirus disease 2019 (COVID-19) using PCR and real-time PCR., Experimental & Molecular Medicine 52, pages963–977(2020)

9. Kim TY, Jeon S, Jang Y, Gotina Lizaveta, Joungha Won, Ju YH, Kim S, Jang MW, Won W, Park MG, Pae AN, Han S, Kim S, Lee CJ, Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome-and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion, Experimental & Molecular Medicine, 2021

Under Review/Accepted article (on 7^th, Jan., 2021)

1. Joungha Won, Pankratov Y, Lee S, Kim A, Jang MW, Lee CJ*., Heo WD*., Opto-vTrap, an optogenetic trap for reversible inhibition of vesicular release, synaptic transmission and behavior., Neuron, Under review

1. EDUCATION:

- B.S. 2002/2 Biotechnology

Department of Biotechnology, Yonsei University, Seoul, Korea

- M.S. 2004/2 Microbialgenetics

School of Biological Sciences, SeoulNationalUniversity,Seoul,Korea

Dissertation Title: “Genetic Engineering to Improve the Zymomonas mobilis ZM4”

Advisor: Hyen Sam Kang, Ph.D.

- Ph.D. 2014/2 Neuroscience

Department of Craniomaxillofacial Cell and Developmental Biology

School of Dentistry,SeoulNationalUniversity,Seoul,Korea

Dissertation Title: “Expression, Function and Regulation of Bestrophin-1 Channel in Astrocyte”

Advisor: Seungbok Lee, Ph.D. and C. Justin Lee, Ph.D.

2. RESEARCH EXPERIENCE:

Jun. 2000 ~ Feb. 2001 Research assistant in Biochemistry and virus laboratory (Advisor: Baik-Lin Seong, Ph.D. professor in Yonsei University)

Sep. 2002 ~ Jun. 2003 Teaching assistant in School of Biological Sciences, Seoul National University

Jan. 2004 ~ Mar. 2005 Research Scientist in Biomedical Center, KIST (Korea Institute of Science and Technology. Advisor: Yeon Gyu Yu, Ph.D. Principal Research Scientist in KIST)

Apr. 2005 ~ Feb. 2016 Research Scientist in Center for Neuroscience, KIST (Korea Institute of Science and Technology. Advisor: C. Justin Lee, Ph.D. Principal Research Scientist in KIST)

Jun. 2012 ~ Jul. 2012 Visiting researcher in The Marine Biological Laboratory (MBL) in Woods Hole

Mar. 2016 ~ Present Senior Research Scientist in Convergence Research Center for Diagnosis, Treatment and Care System of Dementia and Center for Glia-Neuron interaction, KIST (Korea Institute of Science and Technology)

3. PUBLICATIONS :

1. Jeong-Sun Seo, Hyonyong Chong, Hyun Seok Park, Kyoung-Oh Yoon, Cholhee Jung, Jae Joon Kim, Jin Han Hong, Hyungtae Kim, Jeong-Hyun Kim, Joon-Il Kil, Cheol Ju Park, Hyun-Myung Oh, Jung-Soon Lee, Su-Jung Jin, Hye-Won Um, Hee-Jong Lee, Soo-JinOh, Jae Young Kim, Hyung Lyun Kang, Se Yong Lee, Kye Joon Lee and Hyen Sam Kang. “The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4” Nature Biotechnology (2004) 23: 63-68

2. Soo-JinOh, JungHwanPark,SungyuHan,JaeKyunLee,EunJooRohandCJustinLee.“DevelopmentofselectiveblockersforCa2+-activatedCl-channelusingXenopus laevis oocytes with an improved drug screening strategy” Molecular Brain (2008) 1: 14-24 [first author]

3. Yun-Kyoung Kim, Soo-JinOh, Bong-Suk Jin, ChanhooPark,HyesungJeon,DooWanBoo,andYeonGyuYu.“Acell-basedmethodtomonitortheinteractionbetweenhepatitisBviruscapsidandsurfaceproteins”Bulletin of the Korean Chemical Society (2009) 30: 577-581

4. Mihye Lee, Sang Kyoo Paik, Min-Jung Lee, Yoon-Jung Kim, Sungdae Kim, Minyeop Nahm, Soo-JinOh, Hyun-Man Kim, Jeongbin Yim, C. Justin Lee, Yong Chul Bae and Seungbok Lee. “Drosophila atlastin regulates the stability of muscle microtubules and is required for synapse development” Developmental Biology (2009) 330: 250-262

5. HyungjuPark*,Soo-JinOh*, Kyung-Seok Han, Dong Ho Woo, HyekyungPark,GuidoMannaioni,StephenF.Traynelis,andC.JustinLee.“Bestrophin-1encodesfortheCa2+-activatedanionchannelinhippocampalastrocytes” The Journal of Neuroscience (2009) 29: 13063-13073 [*co-first authors]

6. Soojung Lee, Bo-Eun Yoon, Ken Berglund, Soo-JinOh, HyungjuPark,Hee-SupShin,GeorgeJ.Augustine,C.JustinLee.“Channel-mediatedtonicGABAreleasefromglia”Science (2010) 330: 790-796

7. Rae Hyung Ryu, Soo-JinOh, Ra Mi Lee, Seong Won Jeong, Lily Yeh Jan, Chi Ho Lee, C. Justin Lee, Sang Min Jeong. “Cloning and heterologous expression of new xANO2 from Xenopus laevis” Biochemical and Biophysical Research Communications (2011) 408: 559-565

8. Ra Mi Lee, Rae Hyung Ryu, Seong Won Jeong, Soo-JinOh, Hue Huang, Jin Soo Han, Chi Ho Lee, C. Justin Lee, Lily Yeh Jan, and Sang Min Jeong. “Isolation and Expression Profile of the Ca2+-ActivatedChlorideChannel-likeMembraneProtein6GeneinXenopus laevis” Laboratory Animal Research (2011) 27: 109-116

9. Dong Ho Woo, Kyung-Seok Han, Jae Wan Shim, Bo-Eun Yoon, Eunju Kim, Jin Young Bae, Soo-JinOh, Eun Mi Hwang, Alan D. Marmorstein, Yong Chul Bae, Jae-Yong Park, and C. Justin Lee. “TREK-1 and Best1 Channels Mediate Fast and Slow Glutamate Release in Astrocytes upon GPCR Activation” Cell (2012) 151(1): 25-40

10. Soo-Jin Oh, Kyung-Seok Han, Hyungju Park, Dong Ho Woo, Hye Yun Kim, Stephen F. Traynelis, and C Justin Lee. “Protease Activated Receptor 1-induced glutamate release in cultured astrocytes is mediated by Bestrophin-1 channel but not by vesicular exocytosis” Molecular Brain (2012) 5:38 [first author]

11. Soo-JinOh, Seok Jin Hwang, Jonghoon Jung, Kuai Yu, Jeongyeon Kim, Jung Yoon Choi, H.Criss Hartzell, Eun Joo Roh, and C. Justin Lee. “MONNA, a Potent and Selective Blocker for Transmembrane Protein with Unknown Function 16/Anoctamin-1” Molecular Pharmacology (2013) 84:726-735 [first author]

12. Hyungju Park, Kyung-Seok Han, Soo-JinOh, Seonmi Jo, Junsung Woo, Bo-Eun Yoon, and C. Justin Lee. “High glutamate permeability and distal localization of Best1 channel in CA1 hippocampal astrocyte” Molecular Brain (2013) 6:54

13. Seonmi Jo, Oleg Yarishkin, Yu Jin Hwang, Ye Eun Chun, Mijeong Park, Dong Ho Woo, Jin Young Bae, Taekeun Kim, Jaekwang Lee, Heejung Chun, Hyun Jung Park, Da Yong Lee, Jinpyo Hong, Hye Yun Kim, Soo-JinOh, Seung Ju Park, Hyo Lee, Bo-Eun Yoon, YoungSoo Kim, Yong Jeong, Insop Shim, Yong Chul Bae, Jeiwon Cho, Neil W Kowall, Hoon Ryu, Eunmi Hwang, Daesoo Kim and C Justin Lee. “GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease” Nature Medicine (2014) doi:10.1038/nm.3639

14. Seung Eun Lee, Jaekwang Lee, Charles Latchoumane, Boyoung Lee, Soo-JinOh, Zahangir Alam Saud, Cheongdahm Park, Ning Sun, Eunji Cheong, Chien-Chang Chen, Eui-Ju Choi, C. Justin Lee, and Hee-Sup Shin. “Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice” PNAS (2014) 111(32): 11828-11833

15. Bo-Eun Yoon, Junsung Woo, Ye-Eun Chun, Heejung Chun, Seonmi Jo, Jin Young Bae, Heeyoung An, Joo Ok Min, Soo-JinOh, Kyung-Seok Han, Hye Yun Kim, Taekeun Kim, Young Soo Kim, Young Chul Bae, and C. Justin Lee. “Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition” The Journal of Physiology (2014) Sep 19

4. PATENTS :

1. Use of anthranillic acid derivatives on calcium activated chloride channel (#10-0892591 02-Apr-2009)

2. Cellular imaging of the interaction between HBV capsid and surface proteins, and its application for screening of inhibitory ag (#10-0949310 17-Mar-2010)

3. Method for screening a glutamate release inhibitor in an astrocyte (#8,871,463 28-Oct-2014, # 10-1418061 3-Jul-2014)

4. Novel compounds as chloride channel blocking agent (#10-1464280 17-Nov-2014)

5. AWARDS and HONORS :

Brain Korea 21 (BK21) Scholarship (2002 - 2003)

KIST우수연구개발팀상 (2011)

Poster award in 2014 BSI symposium in Korea

Poster award in 2016 The Glia Section of the Korea Society of Brain and Neural Science

Travel award in Japan Neuroscience Society 2016

6. POSTER Presentation :

1. The 12th Japan-Korea Joint symposium on Drug Design and Development Jun-2008

Title: Synthesis and biological activities of anthranilic acid derivatives as Ca2+activatedCl-channelblockers

2. International Society for Neurochemistry Aug-2009

Title: Bestrophin-1 Encodes for the Ca2+ActivatedAnionChannelinhippocampalastrocytes

3. Society For Neuroscience Nov-2010

Title: Astrocytic Ca2+-activatedanionchannel,Bestrophin-1,ispermeabletoglutamateandGABA

4. Society For Neuroscience Nov-2013

Title: MONNA, a potent and selective blocker for TMEM16A/Anoctamin-1

5. The Glia Section of the Korea Society of Brain and Neural Science

Title: Ultrasonic brain stimulation modulates neuronal activity via mechano-sensitive TRPA1 channels in astrocytes Jan-2016

Education

March 2011 – February 2015, Konkuk University, Major: Life science

March 2015 – Present, University of Science & Technology (UST) in Korea, Major: Neuroscience

Work experience

February 2014 – March 2014, Internship program in Korean basic science institute (KBSI), study for two photon microscope confocal microscope with IHC

March 2014 – February 2015, Internship in Korea Institute of science and technology (KIST)

Experienced research skills

Slice Patch, Immunohistochemistry, Confocal imaging, Behavior test (Passive avoidance test, forced swimming test, Rotarod test), Molecular biological techniques (Cloning, Subcloning and RT-PCR, shRNA making), Stereotaxic Surgery, Cell culture (Primary astrocyte, Primary neuron, cell lines)

Publication

Dong Ho Woo,† Jin Young Bae,† Min-Ho Nam,† Heeyoung An, Yeon Ha Ju, Joungha Won, Jae Hyouk Choi, Eun Mi Hwang, Kyung-Seok Han, Yong Chul Bae, and C. Justin Lee (2018). "Activation of Astrocytic mu-opioid Receptor Elicits Fast Glutamate Release Through TREK-1-Containing K2P Channel in Hippocampal Astrocytes." Frontiers in Cellular Neuroscience 12.

Jong-Hyun Park†, Yeon Ha Ju†, Ji Won Choi, Hyo Jung Song, Bo Ko Jang, Junsung Woo, Heejung Chun, Hyeon Jeong Kim, Su Jeong Shin, Oleg Yarishkin, Seonmi Jo, Mijeong Park, Seul Ki Yeon, Siwon Kim, Jeongyeon Kim, Min-Ho Nam, Ashwini M. Londhe, Jina Kim, Sung Jin Cho, Suengmok Cho, Changho Lee, Sung Yeoun Hwang, Sang Wook Kim, Soo-Jin Oh, Jeiwon Cho, Ae Nim Pae, C. Justin Lee, Ki Duk Park (2019). “Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease.” Science Advance 5.

Awards

Oral presentation in KIST - BSI conference (Sep, 2017) _New reversible MAO-B inhibitor KDS2010 abolishes astrogliosis and memory impairment in Alzheimer’s disease model

Poster presentation at Korea Society of Neurodegeneration Disorder (KSND) (Mar, 2018) _ PyrPeg, a Novel Two-photon Probe to Selectively Detect Aβ in Alzheimer’s Disease

undergraduate : 2009.03~2016.02 Korea University

Contact details

Name: Myung sun Park

Date of birth and Place: February 19. 1994, Seoul, Korea

Nationality: Republic of Korea

Home address: 305, 118-28, Sinseong-dong, Yuseong-gu, Daejeon City, South Korea

Tel) 82-10-8949-2583 e-mail) bak100000s@gmail.com

Education and Training

M.S., Hannam University, Daejeon, Republic of Korea, 2016-2018

Department of Biological Science and Biotechnology

B.S., Hannam University, Daejeon, Republic of Korea, 2012-2016

Department of Biological Science and Biotechnology

Dissertation Titles

Abnormality of slow fiber in skeletal muscle of Huntington's disease mouse model (MS).

Professional Experiences

Researcher, Institute for Basic Science, Daegu, Republic of Korea, Daejeon, Republic of Korea, 2018-present

Cognition and Sociality Center

Researcher, Kyungpook National University, Daegu, Republic of Korea, 2018

Medical Research Center

Researcher, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic of Korea, 2016-2018

Aging Research Center

 Publications

 1. Park, M., Min, B., Jeon, K., Cho, S., Park, J. S., Kim, J., . . . Kang, Y. K. (2017). Age-associated chromatin relaxation is enhanced in Huntington's disease mice. Aging (Albany NY), 9(3), 803-822. doi:10.18632/aging.101193

 2. Min, B*., Park, M*., Jeon, K., Park, J. S., Seo, H., Jeong, S., & Kang, Y. K. (2018). Age-associated bimodal transcriptional drift reduces intergenic disparities in transcription. Aging (Albany NY), 10(4), 789-807. doi:10.18632/aging.101428, *co-first author.

Research Presentations

1. “Age-dependent reduction transcriptional disparities”, “Global hypomethylation on large retroelements in aged muscle” Spring Conference of the Korean Society for Gerontology, 2018, poster presentation

2. "Age-associated chromatin relaxation is enhanced in Huntington's disease mice", KSMCB에피유전체학분과 심포지움, 2017, poster presentation